In recent years, the lines between biotechnology, pharmaceuticals, and medical devices have blurred as combination products have introduced paradigm-shifting medical therapies. The success of these products is enabled by the targeted interaction of biomaterials with the human body. Whether at the molecular or macro-scale, biomaterials (including small molecules, polymers, and biologics, among others) are the basic building blocks of any therapeutic product.
While the careful design and deployment of biomaterials has been used successfully to address major clinical needs, the challenges of working with these materials have also proven to be the Achilles' heel of countless medical approaches. Critical deficiencies – including unchecked inflammation, poor mechanical properties, and inadequate stability – have limited the therapeutic potential of biomaterials-driven approaches. Additionally, regulatory scrutiny of new materials has increased, resulting in a dramatically reduced pace of biomaterials innovation.
Arsenal Medical approaches these therapeutic, regulatory, and commercial challenges with our BioActive Composites™ platform. By combining known biomaterials with long track records of clinical use and safety, we can achieve performance that far surpasses that of traditional, monolithic biomaterials. By tuning composite properties to optimize their biological activity at the systems level, we are developing novel therapeutic products that address significant unmet clinical needs.
Benefits of a composites approach to designing biomaterials include:
- • High performance on clinically-relevant parameters, increasing therapeutic efficacy.
- • Multiple design levers to optimize system performance, and reduce development time.
- • Simplified systems that have multiple integrated functions with fewer components, reducing safety concerns, development time, and regulatory risks.
With our BioActive Composites™ platform, we are able to efficiently develop therapeutic systems that can provide a versatile mix of critical clinical product features:
- • Strength
- • Compliance
- • Degradability
- • Biocompatibility
- • Controlled release or absorption of molecules
